Why did he want the part so badly? "It made me cry four or five times," he said of Bruce Joel Rubin's Oscar-winning script in an AP interview.
"Ghost" provided yet another indelible musical moment: Swayze and Moore sensually molding pottery together to the strains of the Righteous Brothers' "Unchained Melody." It also earned a best-picture nomination and a supporting-actress Oscar for Goldberg, who said she wouldn't have won if it weren't for Swayze.
"When I won my Academy Award, the only person I really thanked was Patrick," Goldberg said in March 2008 on the ABC daytime talk show "The View."
Swayze himself earned three Golden Globe nominations, for "Dirty Dancing," "Ghost" and 1995's "To Wong Foo, Thanks for Everything! Julie Newmar," which further allowed him to toy with his masculine image. The role called for him to play a drag queen on a cross-country road trip alongside Wesley Snipes and John Leguizamo.
His heartthrob status almost kept him from being considered for the role of Vida Boheme.
"I couldn't get seen on it because everyone viewed me as terminally heterosexually masculine-macho," he told the AP then. But he transformed himself so completely that when his screen test was sent to Steven Spielberg, whose Amblin pictures produced "To Wong Foo," Spielberg didn't recognize him.
Among his earlier films, Swayze was part of the star-studded lineup of up-and-comers in Francis Ford Coppola's 1983 adaptation of S.E. Hinton's novel "The Outsiders," alongside Rob Lowe, Tom Cruise, Matt Dillon, Ralph Macchio, Emilio Estevez and Diane Lane. Swayze played Darrel "Dary" Curtis, the oldest of three wayward brothers — and essentially the father figure — in a poor family in small-town Oklahoma.
Other '80s films included "Red Dawn," "Grandview U.S.A." (for which he also provided choreography) and "Youngblood," once more with Lowe, as Canadian hockey teammates.
In the '90s, he made such eclectic films as "Point Break" (1991), in which he played the leader of a band of bank-robbing surfers, and the family Western "Tall Tale" (1995), in which he starred as Pecos Bill. He appeared on the cover of People magazine as its "Sexiest Man Alive" in 1991, but his career tapered off toward the end of the 1990s, when he also had stay in rehab for alcohol abuse. In 2001, he appeared in the cult favorite "Donnie Darko," and in 2003 he returned to the New York stage with "Chicago"; 2006 found him in the musical "Guys and Dolls" in London.
Swayze was born in 1952 in Houston, the son of Jesse Swayze and choreographer Patsy Swayze, whose films include "Urban Cowboy."
He played football but also was drawn to dance and theater, performing with the Feld, Joffrey and Harkness Ballets and appearing on Broadway as Danny Zuko in "Grease." But he turned to acting in 1978 after a series of injuries.
Within a couple years of moving to Los Angeles, he made his debut in the roller-disco movie "Skatetown, U.S.A." The eclectic cast included Scott Baio, Flip Wilson, Maureen McCormack and Billy Barty.
Swayze had a couple of movies in the works when his diagnosis was announced, including the drama "Powder Blue," starring Jessica Biel, Forest Whitaker and his younger brother, Don, which was scheduled for release this year.
Off-screen, he was an avid conservationist who was moved by his time in Africa to shine a light on "man's greed and absolute unwillingness to operate according to Mother Nature's laws," he told the AP in 2004.
Swayze is survived by his wife of 34 years, Lisa Niemi. He was 57.